New pyrimidine-N-ß-D-glucosides: synthesis, biological evaluation, and molecular docking investigations

In this study, syntheses of new pyrimidine-coupled N-ß-glucosides and tetra-O-acetyl derivatives were carried out. All glycoconjugates investigated in comparison with known chemotherapeutic agents terms their antimicrobial anticancer functions DNA/protein binding affinities. Spectral data showed that all glycoside obtained by diastereoselectivity as ß-anomers. Both tested groups exhibited strong antiproliferative activity (2.29?66.84 ?g/mL), but some them had sufficiently ideal % cytotoxicity values (10.01%?16.78%). And also synthetic compounds remarkable antibacterial against human pathogenic bacteria. Binding these to CT-DNA resulted significant changes spectral properties, consistent groove binding. Molecular docking studies revealed the score, complex energy, MM-GBSA ?GBind energy experimental results, which potent agents. Overall bioactivity results suggest may be candidates deserve further pharmacological evaluation.